Compounds and methods for modulating adhesion molecule function
AssigneeAdherex Technologies, Inc.
InventorsPatrick Doherty, Orest W. Blaschuk, Barbara J. Gour
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Abstract
Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.
Claims7
A cell adhesion modulating agent capable of binding to the cadherin CAR sequence HAV, wherein the agent comprises at least seven consecutive residues of the HAV-BM sequence:
- Trp-Leu-Aaa-Ile-Asp/Asn-Baa-Caa-Daa-Gly-Gln-Ile (SEQ ID NO:4), wherein Aaa, Baa, Caa and Daa are independently selected from the group consisting of amino acid residues, and wherein the agent modulates a cadherin-mediated process, and wherein the agent consists of no more than 50 amino acid residues of a naturally occurring cadherin.
Dependencies are inferred from the claim text.