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US 6,806,063 B2Granted
Factor VII or VIIa-like molecules
AssigneesMaxygen ApS, Maxygen Holdings Ltd.
InventorsAnders Hjelholt Pedersen, Kim Vilbour Andersen, Claus Bornaes
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Abstract
Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.
Claims24
A conjugate comprising:
- a polypeptide comprising an amino acid sequence which (a) differs from the hFVII or hFVIIa sequence SEQ ID NO:1 in 1-15 amino acid residues and (b) comprises an introduced in vivo N-glycosylation site relative to SEQ ID NO:1, wherein the introduced in vivo N-glycosylation site comprises the substitution T106N;
- and
- a sugar moiety covalently attached to the introduced in vivo N-glycosylation site, wherein the conjugate exhibits at least 25% of the clotting activity of hFVIIa.
Dependencies are inferred from the claim text.