Back to results
US 6,805,784 B2Granted
Capillary array
AssigneeHitachi, Ltd.
InventorsSyozo Kasai, Kiyoshi Tsukada, Toshiaki Kita, Tomonari Morioka
Life of this patent
Estimating the term…
Abstract
The structure of a capillary head section is made such that the liquid contacting surfaces of a capillary holder, a capillary, and an adhesive form a plane surface, and this shared liquid contacting surface is made a mirror surface with a surface roughness of 3.2 s or less. In the shared liquid contacting surface, the ratio of the total area of the capillaries to the internal diameter area of the capillary holder is made 60 to 73%.
Claims42
A capillary array for separating a sample into molecular species thereof comprising:
- a plurality of capillaries having first aligned ends and second aligned ends;
- a detection section arranging and holding said capillaries which are irradiated with electromagnetic waves;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head for injecting an electrophoresis medium at the second aligned ends of the capillaries, wherein
- the aligned second ends of the plurality of capillaries are adhered to each other with adhesive, and a capillary holder having an end bundles the aligned second ends of the plurality of capillaries so that the capillary holder end, the aligned second ends of the plurality of capillaries, and the adhesive adhering the aligned second ends of the capillaries form a plane surface that will contact the electrophoresis medium.
3 more elements
A capillary array for separating a sample into molecular species thereof comprising:
- a plurality of capillaries having first aligned ends and second aligned ends;
- a detection section arranging and holding said capillaries which are irradiated with electromagnetic waves;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head for injecting an electrophoresis medium at the second aligned ends of the capillaries, wherein
- the capillary head comprises a capillary holder that bundles together the second aligned ends of the capillaries;
- the capillaries are adhered together with adhesive;
- the second aligned ends of the capillaries, an end of the capillary holder, and the adhesive together form a plane surface for contacting the electrophoresis medium to be injected into the capillaries;
- and at the electrophoresis medium contacting surface the ratio of the total cross-sectional area of the capillaries in the bundled capillaries to the capillary holder internal diameter area is 60 to 73%.
6 more elements
A capillary array for separating a sample into molecular species thereof comprising:
- a plural number of capillaries having first aligned ends and second aligned ends;
- a detection section arranging and holding said capillaries which are irradiated with electromagnetic waves;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- an electrophoresis medium container adjacent to the second aligned ends of the capillaries;
- and
- a capillary head for injecting the electrophoresis medium from said electrophoresis medium container at the second aligned ends of the capillaries,
- wherein the second aligned ends of the capillaries are adhered to each other with adhesive and the capillary head has a capillary holder that bundles together the second aligned ends of the capillaries, the capillary holder being sealed and fixed using a sealing peg and a tightening knob, and the hardness of each of said capillary holder, of said tightening knob, and of said electrophoresis medium container is greater than the hardness of said sealing peg.
4 more elements
A capillary array for an electrophoresis apparatus comprising:
- a plurality of capillaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head capable of coupling to a mounting part of the electrophoresis apparatus,
- wherein the second aligned ends of the plurality of capillaries are adhered to each other with adhesive, and a capillary holder having an end bundles the aligned second ends of the plurality of capillaries so that the capillary holder end, the aligned second ends of the plurality of capillaries, and the adhesive adhering the aligned second ends of the capillaries form a plane surface that will contact an electrophoresis medium which is injected into the capillaries.
2 more elements
A capillary array for an electrophoresis apparatus comprising:
- a plurality of capillaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head capable of coupling to a mounting part of the electrophoresis apparatus,
- wherein the capillary head comprises a capillary holder that bundles together the second aligned ends of the capillaries,
- the capillaries are adhered together with adhesive,
- the second aligned ends of the capillaries, an end of the capillary holder, and the adhesive together form a plane surface that will contact an electrophoresis medium which is injected into the capillaries, and
- at the plane surface the ratio of the total cross-selectional area of the capillaries in the bundled capillaries to the capillary holder internal area is 60 to 73%.
5 more elements
A capillary assembly for an electrophoresis apparatus comprising:
- a plurality of capillaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capilliaries;
- and
- a capilliary head capable of coupling to a mounting part of a container containing an electrophoresis medium,
- wherein an electrophoresis medium is capable of being provided to the capilliaries via the second aligned ends,
- the second aligned ends of the capilliaries are adhered to each other with adhesive,
- the capilliary head has a capilliary holder bundling together the second aligned ends of the capillaries,
- the capiliary holder is sealed and fixed using a sealing peg and a tightening knob, and
- the hardness of each of the capilliary holder, of the tightening knob, and of the mounting part is greater than the hardness of the sealing peg.
6 more elements
A capilliary assembly for an electrophoresis apparatus comprising:
- a plurality of capilliaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned end of the capilliaries;
- and
- a capilliary head capable of coupling to a mounting part of a container containing an electrophoresis medium,
- wherein the electrophoresis medium is capable of being provided to the capilliaries via the second aligned ends,
- the second aligned ends of the plurality of capilliaries are adhered to each other with adhesive,
- the capilliary head has a capillary holder bundling together the second aligned ends of the capillaries,
- the capilliary holder is sealed and fixed using a sealing peg and a tightening knob, and
- wherein the capilliary holder contacts the sealing peg to form a first contact area, the sealing peg contacts the tightening knob to form a second contact area, and the first contact area is larger than the second contact area.
6 more elements
A capilliary assembly for an electrophoresis apparatus comprising:
- a plurality of capilliaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capilliaries;
- and
- a capilliary head coupled to a mounting part of a container containing an electrophoresis apparatus,
- wherein the electrophoresis medium is capable of being provided to the capilliaries via the second aligned ends, and
- the capilliary head comprises
- a capilliary holder bundling together the second aligned ends of the capilliaries,
- a sealing peg, and
- a tightening knob fixing the capilliary head to the mounting part by rotating the tightening knob without rotating the sealing peg.
6 more elements
A capilliary electrophoresis apparatus comprising:
- an excitation optical system irradiating electromagnetic waves to a plurality of capilliaries;
- a detection optical system detecting fluorescent lights from the capilliaries;
- a container, having a mounting for fluid communication, for holding an electrophoresis medium that is injected into the capilliaries;
- and
- a capilliary assembly which comprises:
- the plurality of capilliaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capilliary head capable of coupling to the mounting part, wherein the second aligned ends of the plurality of capilliaries are adhered to each other with adhesive, and a capilliary holder having an end bundles the second aligned ends of the plurality of capilliaries so that the capilliary holder end, the second aligned ends of the plurality of capilliaries, and the adhesive adhering the second aligned ends of the capilliaries form a plane surface that will contact the electrophoresis medium.
6 more elements
A capilliary electrophoresis apparatus comprising:
- an excitation optical system irradiating electromagnetic waves to a plurality of capilliaries;
- a detection optical system detecting fluorescent lights from the capilliaries;
- a container, fluidly communicating with a mounting part, for holding an electrophoresis medium that is injected into the capilliaries;
- and
- a capilliary assembly which comprises:
- the plurality of capilliaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capilliary head capable of coupling to the mounting part, wherein the capilliary head comprises a capilliary holder that bundles together the second aligned ends of the capilliaries,
- the capilliaries are adhered together with adhesive,
- the second aligned ends of the capilliaries, an end of the capilliary holder, and the adhesive together form a plane surface that will contact the electrophoresis medium which is injected into the capilliaries, and
- at the plane surface the ratio of the total cross-sectional area of the capillaries in the bundled capillaries to the capillary holder internal area is 60 to 73%.
9 more elements
A capillary electrophoresis apparatus comprising:
- an excitation optical system irradiating electromagnetic waves to a plurality of capillaries;
- a detection optical system detecting fluorescent lights from the capillaries;
- a container, fluidly communicating with a mounting part, for holding an electrophoresis medium that is injected into the capillaries;
- and
- a capillary assembly which comprises:
- the plurality of capillaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head capable of coupling to the mounting part, wherein the electrophoresis medium is capable of being provided to the capillaries via the second aligned ends;
- the second aligned ends of the capillaries are adhered to each other with adhesive;
- the capillary head has a capillary holder bundling together the second aligned ends of the capillaries,
- the capillary holder is sealed and fixed using a sealing peg and a tightening knob, and
- the hardness of each of the capillary holder, the tightening knob, and the mounting part is greater than the hardness of the sealing peg.
10 more elements
A capillary electrophoresis apparatus comprising:
- an excitation optical system irradiating electromagnetic waves to a plurality of capillaries;
- a detection optical system detecting fluorescent lights from the capillaries;
- a container, fluidly communicating with a mounting part, for holding an electrophoresis medium that is injected into the capillaries;
- and
- a capillary assembly which comprises:
- the plurality of capillaries having first aligned ends and second aligned ends;
- a plurality of sample injection inlets at the first aligned ends of the capillaries;
- and
- a capillary head capable of coupling to the mounting part, wherein the electrophoresis medium is capable of being provided to the capillaries via the second aligned ends, and
- the capillary head comprises
- a capillary holder bundling together the second aligned ends of the capillaries,
- a sealing peg, and
- a tightening knob fixing the capillary head to the mounting part by rotating the tightening knob without rotating the sealing peg.
10 more elements
Dependencies are inferred from the claim text.