Process for the production of polysiloxane-based polymeric compositions for use in medical devices
AssigneeBausch & Lomb Incorporated
InventorsYu-Chin Lai, Edmond T. Quinn
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Abstract
A process for producing polysiloxane prepolymers of improved homogeneity for use in the production of relatively high refractive index polymeric compositions is described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays. The preferred polymeric compositions are produced through the copolymerization of one or more polysiloxane prepolymers with hydrosilane-containing polysiloxanes.
Claims27
A dialkoxydialkyl silane,
- wherein the R2 groups may be the same or different C1-10 alkyl substituents and R4 is selected from the group consisting of methyl and ethyl, copolymerized with a dialkoxydiaromatic substituted silane and a 1,3-bisvinyl tetraalkyldisiloxane, to produce polysiloxane prepolymers,
- of increased homogeneity, wherein the R1 groups may be the same or different selected from the group consisting of C1-10 alkyl substituents and C6-30 aromatic substituents;
- the R2 groups may be the same or different C1-10 alkyl substituents;
- the R3 groups may be the same or different C6-30 aromatic substituents;
- and x and y may be the same or different natural number with x/x+y at least equal to 0.5.
A dialkoxydiaromatic substituted silane,
- wherein the R3 groups may be the same or different C6-30 aromatic substituents and R4 is selected from the group consisting of methyl and ethyl, copolymerized with a dialkoxydialkyl silane and a 1,3-bisvinyl tetraalkyldisiloxane, to produce polysiloxane prepolymers,
- of increased homogeneity, wherein the R1 groups may be the same or different selected from the group consisting of C1-10 alkyl substituents and C6-30 aromatic substituents;
- the R2 groups may be the same or different C1-10 alkyl substituents;
- the R3 groups may be the same or different C6-30 aromatic substituents;
- and x and y may be the same or different natural number with x/x+y at least equal to 0.5.
A 1,3-bisvinyl tetraalkyldisiloxane,
- wherein the R1 groups may be the same or different selected from the group consisting of C1-10 alkyl substituents and C6-30 aromatic substituents, copolymerized with a dialkoxydialkyl silane and a dialkoxydiaromatic substituted silane, to produce polysiloxane prepolymers,
- of increased homogeneity, wherein the R1 groups may be the same or different selected from the group consisting of C1-10 alkyl substituents and C6-30 aromatic substituents;
- the R2 groups may be the same or different C1-10 alkyl substituents;
- the R3 groups may be the same or different C6-30 aromatic substituents;
- and x and y may be the same or different natural number with x/x+y at least equal to 0.5.
A process for producing polysiloxane prepolymers
- wherein the R1 groups may be the same or different selected from the group consisting of C1-10 alkyl substituents and C6-30 aromatic substituents;
- the R2 groups may be the same or different C1-10 alkyl substituents;
- the R3 groups may be the same or different C6-30 aromatic substituents;
- and x and y may be the same or different natural number with x/x+y at least equal to 0.5, comprising:
- polymerizing a dialkoxydialkyl silane, a dialkoxydiaromatic substituted silane and a 1,3-bisvinyl tetraalkyldisiloxane.
Dependencies are inferred from the claim text.