Equine herpesvirus vaccine
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorMark W. Mellencamp
Life of this patent
Estimating the term…
Abstract
A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus) and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.
Claims33
A vaccine for protecting a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising:
- chemically inactivated EHV-1 KyA virus;
- and
- an adjuvant which includes cross-linked olefinically unsaturated carboxylic acid polymer.
The vaccine of 5 wherein the inactivated equine influenza virus includes inactivated EIV virus subtype A1.
The vaccine of 5 wherein the inactivated equine influenza virus includes inactivated EIV virus subtype A2.
The vaccine of 5 comprising inactivated EIV virus subtype A1 and inactivated EIV virus subtype A2.
A vaccine for protecting a horse against diseases associated with EHV-1 EHV-4 or a combination thereof comprising:
- EHV-1 KyA virus inactivated by treatment with a chemical inactivating agent which includes ethylenimine, binary ethylenimine, acetylethylenimine or a mixture thereof;
- and
- a bioadhesive adjuvant which includes a cross-linked olefinically unsaturated carboxylic acid polymer.
A vaccine for protecting a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising:
- EHV-1 KyA virus inactivated by treatment with a chemical inactivating agent which includes ethylenimine, binary ethylenimine, acetylethyleflimine or a mixture thereof;
- and.
- a bioadhesive adjuvant which includes a cross-linked acrylic acid polymer.
A method for protecting a horse against diseases associated with EHV-1, EHV-4 or a combination thereof comprising:
- administering to said horse a vaccine comprising chemically inactivated EHV-1 KyA virus and an adjuvant which includes cross-linked olefinically unsaturated carboxylic acid polymer.
A kit comprising in combination, (1) a dispenser capable of administering a vaccine to a horse;
- and (2) a composition to protect against diseases associated with EHV-1, EHV-4 or a combination thereof, wherein the composition comprises:
- chemically inactivated EHV-1 KyA virus;
- and
- an adjuvant which includes cross-linked olefinically unsaturated carboxylic acid polymer.
Dependencies are inferred from the claim text.