Delivery of erectile dysfunction drugs through an inhalation route

A composition for delivery of sildenafil, tadalafil or vardenafil comprising a condensation aerosol

• a) formed by volatilizing sildenafil, tadalafil or vardenafil under conditions effective to produce a heated vapor of sildenafil, tadalafil or vardenafil and condensing the heated vapor of sildenafil, tadalafil or vardenafil to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% sildenafil, tadalafil or vardenafil drug degradation products, and
• c) the aerosol has an MMAD less than 3 microns.

A method of producing an erectile dysfunction drug in an aerosol form comprising:

• a) volatilizing an erectile dysfunction drug under conditions effective to produce a heated vapor of the drug, and
• b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the drug comprising less than 5% erectile dysfunction drug degradation products and an aerosol having an MMAD less than 3 μm.

A method of producing sildenafil, tadalafil or vardenafil in an aerosol form comprising

• a) volatilizing sildenafil, tadalafil or vardenafil under conditions effective to produce a heated vapor of sildenafil, tadalafil or vardenafil, and
• b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the sildenafil, tadalafil or vardenafil comprising less than 5% sildenafil, tadalafil or vardenafil degradation products and an aerosol having an MMAD less than 3 μm.