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US 6,800,453 B2Granted
Nucleic-acid programmable protein arrays
AssigneePresident and Fellows of Harvard College
InventorsJoshua Labaer, Albert Lau
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Abstract
Arrays of polypeptides are generated by translation of nucleic acid sequences encoding the polypeptides at a plurality of addresses on the array.
Claims64
A method comprising:
- providing a substrate that comprises a plurality of addresses, each address comprising (i) a nucleic acid encoding a hybrid amino acid sequence comprising a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag;
- contacting each address of the plurality with a translation effector to thereby translate the hybrid amino acid sequence;
- and
- maintaining the substrate under conditions permissive for the hybrid amino acid sequence to bind the binding agent.
1 more element
Dependencies are inferred from the claim text.