Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
AssigneeYeda Research and Development Co. Ltd.
InventorsAlexander Gad, Dora Lis
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Abstract
The present invention provides molecular weight markers for accurate determination of the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases.
Claims10
A method of treating a human afflicted with multiple sclerosis comprising administering to the human a single purified polypeptide, wherein the purified polypeptide comprises consecutive amino acids the amino acid sequence of which is set forth in any of SEQ ID NO:2 or SEQ ID NO:7 in an amount effective to treat the human.
A method of treating a human afflicted with multiple sclerosis comprising administering to the human a pharmaceutical composition comprising a single purified polypeptide, wherein the purified polypeptide comprises consecutive amino acids the amino acid sequence of which is set forth in any of SEQ ID NO:2 or SEQ ID NO:7, in an amount effective to treat the human and a pharmaceutically acceptable carrier.
A method of inhibiting the progression of multiple sclerosis in a human afflicted with multiple sclerosis comprising administering to the human a single purified polypeptide, wherein the purified polypeptide comprises consecutive amino acids the amino acid sequence of which is set forth in any of SEQ ID NO:2 or SEQ ID NO:7, in an amount effective to inhibit the progression of multiple sclerosis in the human.
A method of inhibiting the progression of multiple sclerosis in a human afflicted with multiple sclerosis comprising administering to the human a pharmaceutical composition comprising a single purified polypeptide, wherein the purified polypeptide comprises consecutive amino acids the amino acid sequence of which is set forth in any of SEQ ID NO:2 or SEQ ID NO:7, in an amount effective to inhibit the progression of multiple sclerosis in the human and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.