Diagnosis and treatment of malignant neoplasms
AssigneeRhode Island Hospital
InventorsJack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Abstract
The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
Claims9
A method of inhibiting tumor growth in a tumor-bearing mammal comprising administering to a liver cell of said mammal a compound which inhibits hydroxylation of an aspartic acid or asparagine residue of an EGF-like repeat sequence of a NOTCH polypeptide, said repeat sequence comprising the amino acid sequence of SEQ ID NO:4, by an endogenous human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide, wherein said cell overexpresses said HAAH polypeptide and wherein said HAAH polypeptide comprises the amino acid sequence of SEQ ID NO:2, wherein said compound is a HAAH mutant, said mutant comprising a mutation at position 671, 679, or 690 of SEQ ID NO:2.
Dependencies are inferred from the claim text.