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AssigneeXCYTE Therapies, Inc.
InventorsRonald Berenson, Che Law, Mark Bonyhadi, Narinder Saund, Stewart Craig, Alan Hardwick, Dale Kalamasz, David McMillen
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The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing phenotypically tailored cells, including T-cells for the use in diagnostics, drug discovery, and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having specific phenotypic properties produced by these processes are further provided.
A device adapted for the magnetic attraction of particles in a cell culture comprising a cell culture vessel adapted for the culture of human cells and a magnet or a magnetizable element, wherein said magnet or magnetizable element is positioned within a wall of said culture vessel or external to said culture vessel so as to allow a magnetic field emanating therefrom to pass through said culture vessel.
A method for inducing aggregation of cells or cell surface markers comprising:
Dependencies are inferred from the claim text.