Gastric retention dosage form having multiple layers

A method for treating a subject in need thereof with an active agent, the method comprising:

• administering to the subject a multilayered dosage form which is retained in a stomach of the subject over a prolonged period of time, the dosage form comprising:
• a first layer comprising an amount of swellable polymer, said amount being sufficient to swell said first layer such that said active agent dosage form is retained within the stomach of a subject;
• a second layer laminated with the first layer at a common surface, said second layer comprising a therapeutic amount of an active agent and being formulated to swell to a lesser extent than the first layer;
• and
• at least one band of insoluble material circumscribing only a portion of said first layer and said second layer, said at least one band of insoluble material binding together the first layer and the second layer.