Back to results
US 6,797,276 B1Granted
Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsGregory M. Glenn, Carl R. Alving
Life of this patent
Estimating the term…
Abstract
A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a ystemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement.
Claims11
A method for inducing an antigen specific immune response in a subject comprising:
- a. pretreating an are of the skin of said subject;
- and
- b. applying a formulation to said pretreated area, wherein said formulation comprises:
- 1) at least one antigen sufficient to induce an antigen-specific immune response against a pathogen,
- 2) at least one adjuvant present in an amount effective to induce said immune response to said at least one antigen;
- and,
- 3) a pharmaceutically acceptable carrier, wherein said pretreating enhances skin penetration by said formulation and thereby induces said immune response,
- wherein said pretreating is selected from the group consisting of direct application to said skin, rubbing, swabbing, applying a depilatory agent, applying a keratinolytic formulation, shaving, tape stripping, abrading and a combination thereof.
5 more elements
Dependencies are inferred from the claim text.