Compositions and methods for achieving immune suppression
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsTerry B. Strom, Wlodzimierz Maslinski, Xin Xiao Zheng, Yon Su Kim, Sylvie Ferrari-Lacraz
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Abstract
Disclosed herein are therapeutic compositions containing agents that modulate the immune response in a patient.
Claims20
A therapeutic composition comprising a first agent that targets an interleukin-15 receptor (IL-15R) and a second agent that inhibits a costimulatory signal transmitted between a T cell and an antigen-presenting cell (APC), wherein the first agent comprises a substantially cure mutant IL-15 polypeptide comprising a mutation at position 149 or position 156 of SEQ ID NO:4, and wherein the second agent comprises a substantially pure polypeptide that binds a B7 molecule.
Dependencies are inferred from the claim text.