Conformationally restricted polyamine analogs as disease therapies
AssigneeSLIL Biomedical Corporation
InventorsBenjamin Frydman, Laurence J. Marton, Venodhar K. Reddy, Aldonia Valasinas, Andrei V. Blokhin, Hirak S. Basu
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Abstract
Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to, porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
Claims20
A conformationally restricted polyamine analog of the formula:
- E—NH—B—A—B—NH—B—A—B—NH—B—A—B—NH—B—A—B—NH—E
- wherein each A is independently selected from the group consisting of:
- a single bond, C1-C6 alkyl, and C2-C6 alkenyl;
- each B is independently selected from the group consisting of:
- C1-C6 alkyl and C2-C6 alkenyl;
- and each E is independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C3-C6 cycloaryl, and C3-C6 cycloalkenyl;
- with the proviso that at least one A moiety is selected from the group consisting of C2-C6 alkenyl;
- and any salt or stereoisomer thereof.
A conformationally restricted polyamine analog of the formula:
- E—NH—B—A—B—NH—B—A—B—NH—B—A—B—NH(—B—A—B—NH)x—E
- wherein each A is independently selected from the group consisting of:
- a single bond, C1-C6 alkyl, and C2-C6 alkenyl;
- each B is independently selected from the group consisting of:
- C1-C6 alkyl and C2-C6 alkenyl;
- each E is independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C4 cycloalkyl, C3-C6 cycloaryl, and C3-C6 cycloalkenyl;
- and x is an integer from 2 to 16;
- with the proviso that at least one A moiety is selected from the group consisting of C2-C6 alkenyl;
- and any salt or stereoisomer thereof.
A polyamine analog of the formula:
- E—NH—B—A—B—NH—B—A—B—NH—B—A—B—NH(—B—A—B—NH)x—E
- wherein each A is independently selected from the group consisting of:
- a single bond and C2-C6 alkenyl;
- each B is independently selected from the group consisting of:
- C1-C6 alkyl and C2-C6 alkenyl;
- each E is independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkanol, C3-C6 cycloalkanol, and C3-C6 hydroxyaryl,
- with the proviso that at least one E moiety be selected from the group consisting of C1-C6 alkanol, C3-C6 cycloalkanol, and C3-C6 hydroxyaryl;
- and x is an integer from 0 to 16;
- and any salt or stereoisomer thereof.
Dependencies are inferred from the claim text.