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US 6,787,765 B2Granted
FAIMS with non-destructive detection of selectively transmitted ions
AssigneeIonalytics Corporation
InventorsRoger Guevremont, Randy Purves, David Barnett
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Abstract
Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) with optical based detection of selectively transmitted ions. Light from a light source is directed through an optical port in an electrode of the FAIMS. A light detector is provided for receiving light that is one of transmitted and scattered by the selectively transmitted ions within the FAIMS.
Claims22
An apparatus for separating ions in the gas phase, comprising:
- a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing ions to propagate therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first type of ion along an average ion flow path within the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage;
- an optical port disposed within a surface of one of the two electrodes and adjacent to an ion detecting portion of the analyzer region, the optical port for propagating light including information relating to the selectively transmitted ions therethrough;
- and,
- a light detector disposed external to the ion detecting portion of the analyzer region and in optical communication with the optical port for receiving the light including information relating to the selectively transmitted ions within the ion detecting portion and for providing an electrical signal relating to at least an intensity of the received light.
1 more element
An apparatus for separating ions in the gas phase, comprising:
- a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing ions to propagate therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first type of ion along an average ion flow path within the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage;
- and,
- an optical detector spaced apart from the average ion flow path for receiving light including information relating to the selectively transmitted ions within the average ion flow path so as to support a non-destructive determination of a characteristic of the selectively transmitted ions.
A method for separating ions in the gas phase, comprising the steps of:
- separating a mixture of ions including ions of a first type by selectively transmitting the ions of the first type through an analyzer region of a high field asymmetric waveform ion mobility spectrometer along an average ion flow path between an ion inlet end of the analyzer region and an ion outlet end of the analyzer region;
- detecting light including information relating to the selectively transmitted ions using a light detector that is spaced apart from the average ion flow path;
- and,
- determining a characteristic of the selectively transmitted ions based on the detected light including information relating to the selectively transmitted ions.
1 more element
Dependencies are inferred from the claim text.