2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AssigneePharmacia Corporation
InventorsBarnett S. Pitzele, James A. Sikorski, Ronald Keith Webber
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Abstract
The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H and methyl; and R2 is selected from the group consisting of H and methyl. The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.
Claims12
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H;
- and
- R2 is methyl.
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is hydrogen or methyl.
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is H.
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is methyl.
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H;
- and
- R2 is methyl.
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is selected from the group consisting of H and methyl.
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is H.
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is methyl.
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H;
- and
- R2 is methyl.
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is selected from the group consisting of H and methyl.
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is H.
A compound of Formula III:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is methyl;
- and
- R2 is methyl.
Dependencies are inferred from the claim text.