Carnitine carrier related protein-1
AssigneeGenset S.A.
InventorsJean-Baptiste Dumas Milne-Edwards, Aymeric Duclert, Lydie Bougueleret, Catherine Clusel
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Abstract
The invention concerns CCRP-1 polynucleotides and polypeptides. The invention further relates to methods of directing polynucleotides, polypetides, and small molecules to mitochondria. The invention further relates to methods of reducing blood levels of fatty acids in an individual. The invention also concerns methods of identifying individuals who are at increased risk or who have a predisposition for developing, or present state of having, a diseases or disorder, such as obesity or heart disease, by determining the level of a CCRP-1 gene product in an individual.
Claims14
A composition comprising an isolated, purified, and recombinant polynucleotide, or complement thereof, wherein said polynucleotide comprises a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence encoding amino acids −68 to −1 of SEQ ID NO:2;
- (b) a nucleotide sequence encoding amino acids +1 to 240 of SEQ ID NO:2;
- (c) a nucleotide sequence encoding amino acids −68 to 240 of SEQ ID NO:2;
- (d) a nucleotide sequence encoding a polypeptide fragment of SEQ ID NO:2 having fatty acid metabolizing activity;
- and
- (e) a nucleotide sequence comprising SEQ ID NO:1.
A composition comprising an isolated, purified, and recombinant polynucleotide, or complement thereof, wherein said polynucleotide comprises a fragment of SEQ ID NO:1 selected from the group consisting of:
- (a) a polynucleotide comprising a contiguous span of at least 300 nucleotides of SEQ ID NO:1;
- (b) a polynucleotide comprising nucleotides 280-999 of SEQ ID NO:1;
- (c) a polynucleotide comprising nucleotides 76-999 of SEQ ID NO:1;
- and
- (d) a polynucleotide comprising nucleotides 76-279 of SEQ ID NO:1.
Dependencies are inferred from the claim text.