DNA encoding human JE cytokine
AssigneesDana-Farber Cancer Institute, Inc., Genetics Institute, Inc.
InventorsBarrett J. Rollins, Charles D. Stiles, Gordon G. Wong
Life of this patent
Estimating the term…
Abstract
A novel human cytokine, JE factor, and processes for producing it are disclosed. JE may be used in pharmaceutical preparations for stimulating and/or enhancing immune responsiveness and in wound healing and related tissue repair. containing the factor.
Claims13
An isolated or recombinant DNA as set forth in SEQ ID NO:
- 1.
An isolated or recombinant DNA as set forth from nucleotide 73 to nucleotide 772 of SEQ ID NO:
- 1.
An isolated or recombinant DNA as set forth from nucleotide 160 to nucleotide 369 of SEQ ID NO:
- 1.
An isolated or recombinant DNA as set forth from nucleotide 144 to nucleotide 369 of SEQ ID NO:
- 1.
An isolated or recombinant DNA as set forth from nucleotide 73 to nucleotide 369.
An isolated or recombinant DNA encoding a protein as set forth from amino acid 30 to amino acid 99 of SEQ ID NO:
- 2.
An isolated or recombinant DNA encoding a protein as set forth from amino acid 24 to amino acid 99 of SEQ ID NO:
- 2.
An isolated or recombinant DNA encoding a protein as set forth in SEQ ID NO:
- 2.
An isolated or recombinant DNA which hybridizes to the complement of the sequence of SEQ ID NO:
- 1, wherein said isolated or recombinant DNA hybridizes under hybridization conditions of 4×SSC at 65° C., followed by a washing in 0.1 XSSC at 65° C. for an hour, or under hybridization conditions of 50% formamide, 4×SSC at 42° C., followed by a washing in 0.1×SSC at 65° C. for an hour, and wherein said isolated or recombinant DNA encodes a protein which suppresses tumor formation.
An isolated or recombinant DNA which hybridizes to the complement of DNA as set forth in nucleotide 73 to nucleotide 772 of SEQ ID NO:
- 1, wherein said isolated or recombinant DNA hybridizes under hybridization conditions of 4×SSC at 65° C., followed by a washing in 0.1×SSC at 65° C. for an hour, or under conditions of 50% formamide, 4×SSC at 42° C., followed by a washing in 0.1×SSC at 65° C. for an hour, and wherein said isolated or recombinant DNA encodes a protein which suppresses tumor formation.
An isolated or recombinant DNA which hybridizes to the complement of DNA as set forth in nucleotide 160 to nucleotide 369 of SEQ ID NO:
- 1, wherein said isolated or recombinant DNA hybridizes under conditions of 4×SSC at 65° C., followed by a washing in 0.1×SSC at 65° C. for an hour, or under conditions of 50% formamide, 4×SSC at 42° C., followed by a washing in 0.1×SSC at 65° C. for an hour, and wherein said isolated or recombinant DNA encodes a protein which suppresses tumor formation.
An isolated or recombinant DNA which hybridizes to the complement of DNA as set forth in nucleotide 144 to nucleotide 369 of SEQ ID NO:
- 1, wherein said isolated or recombinant DNA hybridizes under conditions of 4×SSC at 65° C., followed by a washing in 0.1×SSC at 65° C. for an hour, or under conditions of 50% formamide, 4×SSC at 42° C., followed by a washing in 0.1×SSC at 65° C. for an hour, and wherein said isolated or recombinant DNA encodes a protein which suppresses tumor formation.
An isolated or recombinant DNA which hybridizes to the complement of DNA as set forth in nucleotide 73 to nucleotide 369 of SEQ ID NO:
- 1, wherein said isolated or recombinant DNA hybridizes under conditions of 4×SSC at 65° C., followed by a washing in 0.1×SSC at 65° C. for an hour, or under conditions of 50% formamide, 4×SSC at 42° C., followed by a washing in 0.1×SSC at 65° C. for an hour, and wherein said isolated or recombinant DNA encodes a protein which suppresses tumor formation.
Dependencies are inferred from the claim text.