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US 6,787,641 B1Granted
Identification of sel-12 and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsIva Greenwald, Diane Levitan
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AssigneeThe Trustees of Columbia University in the City of New York
InventorsIva Greenwald, Diane Levitan
Estimating the term…
This invention provides an isolated nucleic acid molecule encoding a SEL-12. This invention further provides an isolated nucleic acid molecule which encodes a mutated SEL-12. This invention also provides an isolated nucleic acid molecule which encodes a mutated SEL-12, wherein the mutated SEL-12 contains at least one of the following: position 115 is a leucine, position 132 is an arginine, position 215 is a glutamic acid, position 229 is a valine, position 254 is a valine, position 255 is a valine, position 371 is a valine, position 387 is a tyrosine, position 104 is an isoleucine or position 204 is a valine, This invention further provides different uses of these nucleic acid molecules. This invention also provides different sel-12 mutants and transgenic animals which carry wild-type or mutated sel-12.
An isolated polynucleotide encoding a SEL-12, whose amino acid sequence comprises SEQ ID NO:1.
An isolated polynucleotide encoding SEL-12 having a mutation therein, consisting of an amino acid substitution selected from the group consisting of:
An isolated polynucleotide encoding SEL-12 having therein a mutation selected from the group consisting of a valine substitution at position 229, 254, 255, 371, or 204, which position numbers correspond to the position numbers of SEQ ID NO:1.
The plasmid designated pMX8, deposited with the American Type Culture Collection under Designation No. 97278.
The plasmid designated p1-1E, deposited with the,American Type Culture Collection under Designation No. 97279.
Dependencies are inferred from the claim text.