Resin derivatization method and uses thereof

A method for production of a derivatized resin represented by formula (I):

• R4-NH—(C═X)—Y—Z—SS (I)
• wherein:
• R4 is —NH—R3, —NH2, —OH, or —O—R3, wherein R3 is a protecting group, provided that when R4 is —NH—R3 or —O—R3, then the protecting group is removed and replaced by —H in the final product (I);
• X is O, S, or NR7;
• R7 is H, alkyl, alkenyl, aryl, aralkyl, cycloalkyl, or heterocycle;
• Y is absent, —NH—, or —CH2;
• Z is absent or is a substituent selected from the group consisting of —NH—, —O—, —(C═O)—, —S—, SO2-, alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocycle, provided that when Y is absent and X is O or S, Z does not comprise —(C═O)— immediately adjacent to —(C═X)—, and when Y is —NH— and Z comprises an —NH— or an —S—, at least one carbon atom separates Y and the —NH— or —S— of Z, wherein functional groups of Z are protected;
• SS is a solid support;
• wherein said derivatized resin represented by formula (I) is prepared by a process comprising the steps of:
• (i) reacting a starting material represented by formula (C)
• R1-(C═X)—Y—Z—SS, (C)
• wherein R1 is a leaving group;
• with a reactant of formula (D)
• R4-NH2 (D)
• to form derivatized resin (I) of formula R4-NH—(C═X)—Y—Z SS;
• and
• (ii) recovering the derivatized resin (I);
• wherein said material represented by formula (C) is prepared by a process comprising the step of:
• (iv) reacting a starting material of formula (A)
• R—Y—Z—SS, (A)
• wherein R is a leaving group,
• with a reactant of formula (B)
• R1-(C═X)—R2, (B)
• wherein R2 is a leaving group, same or different than R1, to form said starting material (C) represented by formula
• R1-(C═X)—Y—Z—SS. (C)