Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use
AssigneeInstitute of Materia Medica, Chinese Academy of Medical Sciences
InventorsJuntian Zhang, Liang Huang, Kemei Wu, Shiming Chen
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Abstract
The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.
Claims6
An optically active chiral compound of Formula II,
- selected from the group consisting one of
- 3R4S5S6S (+) epiclausenamide,
- 3S4S5S6R (+) cisclausenamide, 3R4R5R6S (−) cisclausenamide,
- 3S4S5S6S (+) cisepiclausenamide, 3R4R5R6R (−) cisepiclausenamide,
- 3S4S5R6S (−) cisneoclausenamide, 3R4R5S6R (+) cisneoclausenamide,
- 3S4S5R6R (−) cisepineoclausenamide, and 3R4R5S6S (+) cisepineoclausenamide.
A method for the treatment of a neurodegenerative disease comprising administering to a patient suffering from a neurodegenerative disease, an effective treatment amount of an optically active compound selected from the group consisting of
- 3S4R5S6R (−) neoclausenamide, 3R4S5R6S (+) neoclausenamide,
- 3S4R5S6S(−) epineoclausenamide, 3R4S5R6R (+) epioeoclausenamide,
- 3S4R5R6R (−) epiclausenamide, 3R4S5S6S (+) epiclausenamide,
- 3S4S5S6R (+) cisclausenamide, 3R4R5R6S (−) cisclausenamide,
- 3S4S5S6S (+) cisepiclausenamide, 3R4R5R6R (−) cisepiclausenamide,
- 3S4S5R6S (−) cisneoclausenamide, 3R4R5S6R (+) cisneoclausenamide,
- 3S4S5R6R (−) cisepineoclausenamide, and 3R4R5S6S (+) cisepineoclausenamide.
Dependencies are inferred from the claim text.