Sulfonamide compounds

A compound selected from the compounds of Formula (I):

• wherein:
• Z is —OH or OR12 wherein R12 is alkyl;
• R1 is alkyl, haloalkyl, cycloalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocyclylalkyl, cycloalkylalkyl, -(alkylene)-C(O)—X where X is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, hydroxy, alkoxy, cycloalkoxy, cycloalkylalkoxy, heteroalkyloxy, aralkyloxy, or heteroaralkyloxy), —C(═NR′)NHSO2R″ (where R′ is hydrogen or alkyl, and R″ is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, or heterocyclylalkyl), or heteroalkyl, wherein said heteroalkyl is an alkyl, cycloalkyl, or cycloalkylalkyl carrying a substituent selected from —NRaRb, —ORc, or —S(O)nRd wherein
• n is an integer from 0 to 2;
• Ra is hydrogen, alkyl, or —COR (where R is hydrogen, alkyl, or haloalkyl);
• Rb is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, heterocyclyhydroxyalkyl, —COR (where R is hydrogen, alkyl, haloalkyl, monosubstituted aminoalkyl, aryloxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclylalkyl), or -(alkylene)-C(O)—X (where X is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, amino, monosubstituted amino, disubstituted amino, aryl), aralkyl, heteroaryl, heteroalkyl, heterocyclyl, or heterocyclyalkyl), —SO2R (where R is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino or disubstituted amino), —COOR (where R is hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, or heterocyclylalkyl), —CONR′R″, or -(alkylene)-CONR′R″ [where R′ and R″ are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, aryl, aralkyl, heteroaryl, heteroaralkyl, or SO2R (where R is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino or disubstituted amino), or R′ and R″ together with the nitrogen atom to which they are attached form a heterocyclyl ring];
• Rc hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroalkyl, heterocyclylalkyl, —COR (where R is alkyl, haloalkyl, or heteroalkyl), or —CONR′R″ (where R′ and R″ are independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl);
• and Rd is hydrogen (provided that n is 0), alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino, or disubstituted amino;
• and
• Rd is hydrogen (provided that n is 0), alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, amino, monosubstituted amino, or disubstituted amino;
• R is —CH(R2)Ar1 or —CH(R2)CH═CHAr1 where R2 is hydrogen or alkyl;
• and Ar1 is heteroaryl selected from indol-5-yl, 1-methylindol-5-yl, 3acetylindol-5-yl, 3-propionylindol-5-yl, 3-(2-methylpropionyl)indol-5-yl, imidazol-5-yl, 2-methylbenzimidazol-5-yl, benzimidazol-5-yl, benzoxazol-5-yl, 3-[1-(hydroxymino)propyl]indol-5-yl, and 3-[(N-benzyloxy)methylimidoyl]indol-5-yl;
• Ar2 is either;
• (i) a phenyl ring of formula (a):
• wherein:
• R3 and R7 are, independently of each other, hydrogen, alkyl, alkylthio, or halo;
• R4 and R6 are, independently of each other, hydrogen, alkyl, or halo;
• R5 is alkyl, haloalkyl, heterocyclyl, alkylthio, arylthio, aralkylthio, heteroarylthio, heteroaralkylthio, cycloalkylthio, cycloalkylalkylthio, alkoxy, aryloxy, aralkoxy, heteroaryloxy, heteroaralkyloxy, cycloalkoxy, cycloalkylalkoxy, alkyloxycarbonyl, hydroxy, halo, cyano, carboxy, nitro, amino, monoalkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, heteroarylsulfonyl, heteroaralkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfonyl, or —Y-(alkylene)-C(O)—Z [where Y is a bond, —NRa—, —O—, or —S(O)n— (where n is 0 to 2), R8 is hydrogen or alkyl, and Z is alkoxy, hydroxy, amino, monosubstituted amino, or disubstituted amino];
• or
• R3 together with R4 forms —O—(CR8R9)n— where n is 2 or 3 and each R8 and R9 are, independently of each other, hydrogen or alkyl;
• or
• the carbon atoms to which R5 and R4 are attached are fused to the C2-C3 carbons of a benzofuran ring;
• provided that at least two of R3, R4, R6, and R7 are not hydrogen at the same time;
• or
• (ii) a naphthyl ring of formula (b):
• wherein:
• R10 is hydrogen, alkyl, alkoxy, or halo;
• and
• R11 is hydrogen, alkyl, haloalkyl, alkylthio, alkoxy, alkyloxycarbonyl, aryloxy, hydroxy, halo, cyano, carboxy, nitro, amino, monoalkylamino, dialkylamino or alkylsulfonyl provided that both R10 and R11 are not hydrogen at the same time;
• and
• their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers.