Benzoic acid derivatives for the treatment of diabetes mellitus

A method for treatment of type 2 diabetes, treatment of insulin resistance syndrome (IRS), treatment of dyslipidemia or reducing the risk of cardiovascular disease comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I)

• or a pharmaceutically acceptable salt or ester thereof, optionally in combination with a pharmaceutically acceptable excipient, where Q, X, Y and Z are either —CRa═, —CRb═CRc— or —N═;
• where Ra, Rb and Rc are independently selected from hydrogen, halo or a bond, such that together with the nitrogen atom to which Y and Z are attached, they form a five- or six-membered aromatic ring;
• R1 and R3 are independently selected from C1-3alkyl, halo, haloC1-3alkyl, C1-3alkoxy, or haloC1-3alkoxy;
• n and m are independently selected from 0, 1 or 2;
• A is an alkylene, alkenylene or alkynylene chain optionally interposed by a heteroatom;
• and
• R2 is an optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted cycloalkyl moiety.