Triazole compounds useful in treating diseases associated with unwanted cytokine activity
AssigneeThe Procter & Gamble Company
InventorsJoshua Spector Tullis, John Charles Van Rens, Michael Philip Clark, Benjamin Eric Blass, Michael George Natchus, Biswanath De
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Abstract
The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.
Claims9
A compound having the formula:
- wherein R1 is chosen from fluoro and chloro;
- R4 is chosen from hydrogen, methyl, isopropyl, phenyl, benzyl, 4-methylbenzyl, 4-methoxybenzyl, 4-fluorobenzyl (S)-1-phenylethyl, and (R)-1-phenylethyl;
- A and B are each chosen from methylcarbonyl, furan-2-ylcarbonyl, phenylcarbonyl, 4-methoxyphenylcarbonyl, 4-chlorophenylcarbonyl, ethoxycarbonyl, phenylthio-thiocarbonyl, phenylmethoxycarbonyl 2-methoxyethoxycarbonyl methoxymethyl,(2-methoxyethoxy)-methyl, phenylmethoxymethyl, 2-methoxymethyl, 2-ethoxymethyl, 2-phenoxyethyl, methylsulfonyl, pheylsulfonyl, 2-furansulfonyl, N-ethyl-N-phenylaminocarbonyl, 2,3-dihydroindol-1-ylcarbonyl, N,N-dimethylaminocarbonyl, tetrahydrofuranyl-N-carbonyl, morpholino-N-carbonyl, piperidyl-N-carbonyl, pyrrol-2-ylcarbonyl and pyrrol-3-carbonyl.
Dependencies are inferred from the claim text.