US 6,787,551 B2 · Thiazolidinedione derivatives and pharmaceutical composition comprising the same

Abstract

The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof. Further, the present invention provides a pharmaceutical composition comprising the compound represented in formula (1) below, wherein: X represents a carbon or nitrogen atom, Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group, Z represents an oxygen, nitrogen, or sulfur atom, and R1 and R2 each represent a hydrogen atom; or R1 and R2 together form a bond.

Claims10

Dependent claims

A thiazolidinedione compound, represented in formula (1):

wherein:
X represents a carbon or nitrogen atom;
Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group;
Z represents NH, an oxygen, or sulfur atom;
and R1 and R2 each represent a hydrogen atom, or R1 and R2 together form a bond,
a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof.

3 more elements

A diabetes therapeutic agent for oral administration, comprising an effective active component selected from a thiazolidinedione compound, represented in formula (1), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof;

and a pharmaceutically acceptable carrier:
wherein:
X represents a carbon or nitrogen atom;
Y represents a hydrogen atom, a C1-C4 alkyl group, a C1-C3 alkoxy group, chlorine, fluorine or a phenyl group;
Z represents NH, an oxygen, or sulfur atom;
and R1 and R2 each represent a hydrogen atom, or R1 and R2 together form a bond.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/250,502Filed 3 Jul 2003

Priority

KR 2002-1575522 Mar 2002

Published

US 2004/0122031 A124 Jun 2004

Granted

7 Sep 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 417/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents
A61P 3/06
Drugs for disorders of the metabolism: antihyperlipidemics
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics

Thiazolidinedione derivatives and pharmaceutical composition comprising the same

Life of this patent

Thiazolidinedione derivatives and pharmaceutical composition comprising the same

Life of this patent

Abstract

Claims10