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US 6,787,548 B1Granted
Thienopyrimidines as phosphodiesterase inhibitors
AssigneeMerck Patent GmbH
InventorsRochus Jonas, Pierre Schelling, Franz-Werner Kluxen, Maria Christadler
Life of this patent
Estimating the term…
Abstract
Thienopyrimidines of the formula I and their physiologically acceptable salts, in which R1, R2 and X have the meanings indicated in claim 1, exhibit phosphodiesterase V inhibition and can be employed for the treatment of disorders of the cardiovascular system and for the treatment and/or therapy of potency disorders.
Claims21
A compound of formula I or a physiologically acceptable salt thereof
- in which
- R1, R2 in each case independently of one another are H, A, OH, OA or Hal,
- X is R4, R5 or R6, which is monosubstituted by R7,
- R4 is linear or branched alkylene having 1-10 C atoms, in which one or two CH2 groups are optionally replaced by —CH═CH— groups,
- R5 is cycloalkyl or cycloalkyl alkylene having 5-12 C atoms,
- R6 is phenyl or phenylmethyl,
- R7 is COOH, COOA, CONH2, CONHA, CON(A)2 or CN,
- A is alkyl having 1 to 6 C atoms and
- Hal is F, Cl, Br or I,
- where at least one of the radicals R1 or R2 is OH.
7 more elements
Dependencies are inferred from the claim text.