Nitrogen-containing heterocyclic carboxamide derivatives or salts thereof and antiviral agents comprising the same
AssigneeToyama Chemical Co., Ltd.
InventorsYousuke Furuta, Hiroyuki Egawa, Nobuhiko Nomura
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Abstract
Nitrogen-containing heterocyclic carboxamide derivatives represented by the following general formula: wherein ring A is a substituted or unsubstituted pyrazine, pyrimidine, pyridazine or triazine ring; R1 is O or OH; R2 is a hydrogen atom, an acyl group or a substituted or unsubstituted carbamoylalkyl or carboxyalkyl group; and the broken line represents a single bond or a double bond; or salts thereof are useful for preventing and treating virus infections and especially influenza virus infections.
Claims18
A nitrogen-containing heterocyclic carboxamide compound represented by the following formula
- wherein:
- each occurrence of R3 is independently a halogen atom, a hydroxyl group, or an oxide group;
- R1 represents O or OH;
- R2 is selected from the group consisting of a hydrogen atom, an acyl group, an optionally substituted carbamoylalkyl group, and an optionally substituted carboxyalkyl group;
- n is 1, 2, 3, or 4;
- and
- the broken line in the ring represents a single bond when R1 is O and a double bond when R1 is OH;
- or a pharmaceutically acceptable salt thereof.
A method of treating a viral condition associated with influenza virus, C-type hepatitis, rhino virus, or respiratory syncytial virus by administering, to a patient in need thereof, an effective amount of at least one compound or a pharmaceutically acceptable salt thereof, the compound having a structure according to the following formula
- wherein:
- ring A represents a pyrazine, pyrimidine, pyridazine or triazine ring, ring A is optionally substituted with at least one of a halogen atom, a hydroxyl group, an oxide group, a phenyl group, a pyridinyl group, and a mercapto group;
- R1 represents O or OH;
- R2 is selected from the group consisting of a hydrogen atom, an acyl group, an optionally substituted carbamoylalkyl group, and an optionally substituted carboxyalkyl group;
- and
- the broken line is one of a single bond and a double bond.
Dependencies are inferred from the claim text.