Indole derivatives with 5HT6 receptor affinity

A compound of Formula I comprising:

• wherein:
• R1 is —SO0-2—A, —C(O)—A, or —(CH2)0-1—A, wherein A is aryl or heteroaryl, said heteroaryl being monovalent aromatic carbocyclic radical having one or two rings incorporating one, two, or three heteroatoms chosen from nitrogen, oxygen, or sulfur;
• said aryl and heteroaryl are each independently in each occurrence optionally substituted with one or more groups selected from hydroxy, cyano, C1-6-alkyl, C1-6-alkoxy, thio-C1-6-alkyl, halo, halo-C1-6-alkyl, hydroxy-C1-6-alkyl, nitro, C1-6-alkoxycarbonyl, C1-6-alkylcarbonyl, C1-6-alkylsulfonyl, halo-C1-6-alkylsulfonyl, amino, C1-6-alkylamino, di-C1-6-alkylamino, C1-6-alkylaminocarbonyl, C1-6-alkylcarbonylamino, C1-6-alkylaminosulfonyl, and C1-6-alkylsulfonylamino;
• R2 is selected from hydrogen, C1-6-alkyl, C1-6-alkoxy, and C1-6-alkylthio;
• R3 is selected from hydrogen and C1-6-alkyl;
• R7 is a group of general Formula B, wherein W is a nitrogen atom, and R8, R9 and
• R10 are each independently selected from hydrogen and C1-C10-alkyl;
• and R4, R5 and R6 are each independently of each other selected from hydrogen, halogen, C1-6-alkyl, C1-6-alkylthio, halo-C1-6-alkyl, cyano, and C1-6-alkylcarbonyl;
• or individual isomers, racemic or non racemic mixtures of isomers, prodrugs, or pharmaceutically acceptable salts or solvates thereof.

A compound of Formula I comprising:

• wherein:
• R1 is —S(O)0-2—A, —C(O)—A, or —(CH2)0-1—A, wherein A is aryl or heteroaryl, said heteroaryl being a monovalent aromatic carbocyclic radical having one or two rings incorporating one, two, or three heteroatoms chosen from nitrogen, oxygen, or sulfur;
• and said aryl and heteroaryl are each independently of each other in each occurrence optionally substituted with one or more groups selected from hydroxy, cyano, C1-6-alkyl, C1-6-alkoxy, thio-C1-6-alkyl, halo, halo-C1-6-alkyl, hydroxy-C1-6-alkyl, nitro, C1-6-alkoxycarbonyl, C1-6-alkylcarbonyl, C1-6-alkylsulfonyl, halo-C1-6-alkylsulfonyl, amino, C1-6-alkylamino, di-C1-6-alkylamino, C1-6-alkylaminocarbonyl, C1-6-alkylcarbonylamino, C1-6-alkylaminosulfonyl, and C1-6-alkylsulfonylamino;
• R2 is selected from hydrogen, C1-6-alkyl, C1-6-alkoxy, and C1-6-alkylthio;
• R3 is selected from hydrogen and C1-6-alkyl;
• R5 is a group of general formula B, wherein W is a nitrogen atom, and R8, R9 and R10 are each independently selected from hydrogen and C1-10-alkyl;
• and R4, R6 and R7 are each independently of each other selected from hydrogen, halogen, C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, halo-C1-6-alkyl, cyano, and alkylcarbonyl;
• or individual isomers, racemic or non racemic mixtures of isomers, prodrugs, or pharmaceutically acceptable salts or solvates thereof.