Sulfonamide-containing heterocyclic compounds

A compound of formula (I), a pharmacologically acceptable salt or hydrates thereof:

• wherein A in formula (I) is a hydrogen atom, halogen atom, hydroxyl group, C1-C4 alkyl group or alkoxy group which may be substituted with a halogen atom, cyano group, —(CO)kNR2R3 (wherein, R2 and R3 are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and k means 0 or 1), C2-C4 alkenyl group or alkynyl group which may have a substituent, or a phenyl group or phenoxy group which may have a substituent selected from the following group A;
• B is an aryl group or monocyclic heteroaryl group which may have a substituent selected from the following group A, or
• (wherein, the ring Q is an aromatic ring which may have one or two nitrogen atoms;
• the ring M is an unsaturated C5-C12 monocyclic or polycyclic ring which shares a double bond with the ring Q, and the ring may have 1 to 4 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom;
• the ring Q and the ring M may share nitrogen atom with each other;
• and the ring Q and the ring M may each have a substituent selected from the following group A);
• K is a single bond or —(CR4R5)m— (wherein, R4 and R5 are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group;
• and m is an integer of 1 or 2);
• one of T, U, V, W, X and Y is a nitrogen atom and the rest are ═C(D)— (wherein D is a hydrogen atom, halogen atom, hydroxyl group, C1-C4 alkyl group or alkoxy group which may be substituted by a halogen atom, cyano group, —(CO)nNR6R7 (wherein R6 and R7 are the same as or different from each other and each means a hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and n means 0 or 1), or a C2-C4 alkenyl group or alkynyl group which may have a substituent);
• Z is a single bond or —CO—NH—;
• R1 is a hydrogen atom or a C1-C4 alkyl group;
• and
• means a single or double bond,
• Group A is a halogen atom, hydroxyl group, C1-C4 alkyl group or alkoxy group which may be substituted by a halogen atom, cyano group, —R8R9N(NH)p— (wherein R8 and R9 are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and p means 0 or 1, and R8 and R9 may be combined with the nitrogen atom to which they bound to form a 5- or 6-membered ring which may further include a nitrogen atom, oxygen atom or sulfur atom and may have a substituent), an aminosulfonyl group which may be substituted with one or two C1-C4 alkyl groups, an optionally substituted C1-C8 acyl group, a C1-C4 alkyl-S(O)s-C1-C4 alkylene group (wherein s means an integer of 0, 1 or 2), a phenylsulfonylamino group which may have a C1-C4 alkyl or a substituent, —(CO)qNR10R11 (wherein R10 and R11 are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with an amino group which may be substituted with a halogen atom or a C1-C4 alkyl group;
• and q means 0 or 1), or an aryl or heteroaryl group which may have a substituent,
• provided that the following cases are excluded:
• 1) A and D are both hydrogen atoms;
• 2) when Y is a nitrogen atom, then T, U, V, X and Y are ═C(D2)—, wherein D2 is a hydrogen atom, K and Z are single bonds, A is a hydroxyl group, and B is a p-tolyl group.