Topical composition

A substantially non-aqueous pharmaceutical gel composition for application on skin, said composition comprising

• at least one vitamin D analogue selected from the group consisting of seocalcitol;
• calcipotriol;
• hydrate of calcipotriol;
• calcitriol;
• tacalcitol, maxacalcitol;
• paricalcitol;
• falecalcitriol;
• 1α, 24S-dihydroxy-vitamin D2;
• and 1(S),3(R)-dihydroxy-20(R)-[((3-(2-hydroxy-2-propyl)-phenyl)-methoxy)-methyl]-9,10-secopregna-5(Z),7(E),10(19)-triene and mixtures thereof,
• at least one corticosteroid,
• a viscosity-increasing excipient in an amount resulting in a viscosity in the range of from about 5 mPa.s to about 500 mPa.s, and
• at least one solvent selected from the group consisting of:
• (i) compounds of the general formula R3(OCH2C(R1)H)xOR2 (I) wherein x is in the range of 2-60, R1 in each of the x units independently is H or CH3, R2 is straight chain or branched C1-20alkyl or benzoyl, and R3 is H or phenylcarbonyloxy;
• (ii) di-(straight or branched)-C4-10 alkyl esters of C4-C8 dicarboxylic acids;
• (iii) straight or branched C12-18-alkyl benzoates;
• (iv) straight or branched C2-4-alkyl esters of straight or branched C10-18-alkanoic or -alkenoic acids;
• (v) propylenglycol diesters with C8-14-alkanoic acids;
• and
• (vi) branched primary C18-24 alkanols, said composition being stable when stored at 40° C. for 3 months.