Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
AssigneeIdenix Pharmaceuticals, Inc.
InventorsMartin L. Bryant, Jean-Pierre Sommadossi
Life of this patent
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Abstract
A method and composition for treating a host infected with hepatitis D comprising administering an effective hepatitis D treatment amount of a described 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof.
Claims25
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of a biologically active 2′-deoxy-β-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt thereof in combination or alternation with interferon to a host in need thereof.
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of 2′-deoxy-β-L-erythro-pentofuranonucleoside of the formula:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative;
- and
- BASE is a purine or pyrimidine base that may optionally be substituted;
- in combination or alternation with interferon to a host in need thereof.
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of a β-L-2′-deoxycytidine of the formula:
- or pharmaceutically acceptable salt thereof, wherein R1 is H, mono, di or triphosphate, acyl, alkyl, or a stabilized phosphate derivative;
- in combination or alternation with interferon to a host in need thereof.
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of a β-L-thymidine of the formula:
- or pharmaceutically acceptable salt thereof, wherein R1 is H, mono, di or triphosphate, acyl, alkyl or a stabilized phosphate derivative;
- in combination or alternation with interferon to a host in need thereof.
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of a β-L-2′-deoxycytidine of the formula:
- or pharmaceutically acceptable salt thereof,
- in combination or alternation with interferon.
A method for treating a host infected with hepatitis D virus comprising administering an effective hepatitis D treatment amount of a β-L-thymidine of the formula:
- or pharmaceutically acceptable salt thereof,
- in combination or alternation with interferon.
Dependencies are inferred from the claim text.