Glyceryl nucleotides, method for the production thereof and their use

A compound of the formula I,

• in racemic or enantiomerically pure form,
• in which
• the radical A and the two phosphorus-containing radicals are linked, in any arbitrary sequence, to the C atoms C1, C2 and C3 of the glycerol backbone;
• wherein each of said C atoms carries one of said radicals;
• X1, X2, X3 and X4 are identical or different and, independently of each other, are oxygen or sulfur;
• A is alkyl, hydroxyl, mercapto, alkyloxy or acyloxy, where the alkyl or acyl radicals are linear or branched, possess from 1 to 24 C atoms, optionally possess up to 2 double bonds and are optionally substituted by from 1 to 3 aromatic radicals;
• Z is hydrogen or the corresponding salt of the acid form of this compound;
• one of the radicals N1 and N2 is —C(═O)—OH or a salt form thereof and the other of the radicals is the radical of a D- or L-configured nucleoside derivative;
• or the two radicals N1 and N2 are different from each other and are in each case a radical of a D- or L-configured nucleoside derivative, where the nucleoside radicals are selected from radicals of the general formulae II, III and IV
• or the tautomeric forms thereof, in which
• Y is oxygen or sulfur;
• R1 is a hydroxyl or amino or an acylated, alkylated or polyoxyethylene-substituted amino group, whose acyl or alkyl radical is linear or branched, possesses from 1 to 24 C atoms and optionally possesses up to 2 double bonds and can be substituted by an aromatic radical;
• R2 is hydrogen, halogen, an amino or hydroxyl group, or a bromovinyl or a linear or branched C1-C24 alkyl radical;
• and
• R3, R4, R5, R6 and R7 are identical or different and are hydrogen, halogen, hydroxyl, ethynyl or azido;
• the radical R8 being —O— by way of which the nucleoside derivative radical is linked to the phosphorus atom, with the proviso that two of the vicinal radicals R3 to R8 are dispensed with when a C═C double bond is present in position a.