Prevention and treatment of amyloidogenic disease
AssigneeNeuralab Limited
InventorDale B. Schenk
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
Claims24
A method of preventing or treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ peptide, the adjuvant enhancing the immune response to the Aβ peptide, and thereby prevent or treat the disease in the patient.
A method of preventing or treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide in a regime effective to induce an immune response comprising antibodies to the Aβ peptide and thereby prevent or treat the disease in the patient, wherein the dose of Aβ peptide administered to the patient at least 50 μg.
A method of preventing or treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide in a regime effective to induce an immune response comprising antibodies to the Aβ peptide and thereby prevent or treat the disease in the patient;
- and monitoring the patient for the immune response, wherein the monitoring comprises detecting antibodies having Aβ peptide binding specificity.
Dependencies are inferred from the claim text.