Therapeutics of osteoarthritis and inflammatory joint disease
OwnerYukio Kato, Masahiro Iwamoto +1inventors
InventorsYukio Kato, Masahiro Iwamoto, Tatsuya Koike
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Abstract
Drugs for preventing or treating diseases that involve the destruction and degeneration of articular cartilage tissue contain a parathyroid hormone related peptide (PTHrP) or a PTHrP derived substance as an effective ingredient.
Claims6
A method for suppressing the incorporation of calcium into chondrocytes or the calcification of cartilage and subchondral bone, comprising
- administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
A method for suppressing the formation of type X collagen in cartilage, subchondral bone or chondrocytes, comprising
- administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
A method for suppressing the alkali phosphatase activity in cartilage, subchondral bone or chondrocytes, comprising
- administering to a patient suffering from a disease that involves the destruction and degeneration of articular cartilage tissue, a therapeutically effective amount of a parathyroid hormone related peptide (PTHrP) or a PTHrP derivative substance comprising amino acids 1-34 of PTHrP.
Dependencies are inferred from the claim text.