Plasma-derived fibrin-based matrices and tissue
AssigneeVirginia Commonwealth University
InventorsGary L. Bowlin, Gary Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr, Helen Fillmore
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Abstract
The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or “organ-like” tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.
Claims15
Engineered tissue comprising a suspension of anticoagulated plasma, a clotting agent, a fibrinolytic, inhibitor and cells.
A method of manufacturing an engineered tissue comprising mixing cells with anticoagulated plasma and a clot agent, a fibrinolytic inhibitor to form a suspension.
Dependencies are inferred from the claim text.