β-amyloid peptide-binding proteins and polynucleotides encoding the same
AssigneeAmerican Home Products Corporation
InventorsBradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia, David Howland
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Abstract
Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.
Claims16
An isolated protein comprising the amino acid of SEQ ID NO:
- 2.
An isolated protein comprising the amino acid sequence encoded by cDNA insert of clone BBP1-fl deposited under accession number ATCC 98617.
An isolated protein comprising the amino acid of SEQ ID NO:
- 2 from amino acid 68 to amino acid 269.
A non-naturally occurring fusion protein comprising the amino acid sequence of SEQ ID NO:
- 2 linked to a peptide sequence.
A non-naturally occurring fusion protein comprising amino acid 185 to amino acid 217 of SEQ ID NO:
- 2.
A fusion protein comprising the amino acid sequence of SEQ ID NO:
- 2 from amino acids 68 to 269 with two regions of sufficient length and hydrophobicity to transverse a cellular membrane as deposited under the accession number ATCC 98399.
A recombinant protein comprising amino acid 123 to amino acid 202 of SEQ ID NO:
- 2.
An isolated protein comprising the amino acid sequence from amino acid 185 to amino acid 217 of SEQ ID NO:
- 2.
A recombinant protein comprising amino acid 185 to amino acid 217 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.