Electrospray apparatus for mass fabrication of chips and libraries
AssigneeNew York University
InventorsVictor Morozov, Tamara Ya Morozova
Life of this patent
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Abstract
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to determine the interaction of the deposited non-volatile substances to other substances. Also included in this method is the mass fabrication on a single chip of an array of single and multicomponent microsamples.
Claims24
An apparatus for depositing a sample of a nonvolatile biologically functional and/or biologically active substance onto a deposit area of a substrate by electrospraying a solution comprising a non-volatile biologically functional and/or biologically active substance, the apparatus comprising:
- an electrosprayer for creating from the solution, in a gas-filled space, a mist of charged particles including the non-volatile biologically functional and/or biologically active substance;
- and
- an electrophotic means for creating, selectively by illumination or non-illumination;
- a first potential, attractive to the charged particles, on the deposit areas of the substrate surface, and
- a second potential, not attractive to the charged particles, on areas of the substrate surface other than the deposit areas.
An apparatus for depositing a sample of a nonvolatile biologically functional and/or biologically active substance onto a deposit area of a substrate by electrospraying a solution comprising a non-volatile biologically functional and/or biologically active substance, the apparatus comprising:
- an electrosprayer for creating from the solution, in a gas-filled apace, a mist of charged particles including the non-volatile biologically functional and/or biologically active substance;
- a first electrostatic device holding a surface of the substrate adjacent to the deposit area at a first potential attractive to the charged particles;
- and
- a mask held at a potential repulsive to the charged particles, the mask being disposed a distance above the surface of the substrate, the mask including a hole therethrough located above the deposit area;
- wherein a size of the hole is in a predetermined ratio to the distance, and wherein the predetermined ratio, the first potential, and the second potential generate an electric field in a region of the hole whereby the charged particles are focused and the deposit area is smaller than a hole area of the hole.
An apparatus for depositing a sample of a nonvolatile biologically functional and/or biologically active substance onto a deposit area of a substrate by electrospraying a solution comprising a non-volatile biologically functional and/or biologically active substance, the apparatus comprising:
- an electrosprayer for creating from the solution, in a gas-filled apace, a mist of charged particles including the non-volatile biologically functional and/or biologically active substance;
- a first electrostatic device holding a surface of the substrate adjacent to the deposit area at a first potential attractive to the charged particles;
- and
- a mask held at a potential repulsive to the charged particles, the mask being disposed a distance above the surface of the substrate, the mask including a hole therethrough located above the deposit area, wherein the mask reaches the second potential by incorporating charge from the charged particles;
- wherein a size of the hole is in a predetermined ratio to the distance, and wherein the predetermined ratio, the first potential, and the second potential generate an electric field in a region of the hole whereby the charged particles are focused and the deposit area is smaller than a hole area of the hole.
Dependencies are inferred from the claim text.