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AssigneeAlton Ochsner Medical Foundation
InventorsAndrew L. Mason, Lizhe Xu, Linsheng Guo
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The present invention relates first, to the identification of a retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH) Crohn's disease and ulcerative colitis. The present invention further relates to methods for using the PSC associated retroviral nucleotides for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in patient samples. The present invention also relates to methods for using and targeting the PSC associated retroviral POL nucleotides in gene therapy protocols for the treatment of PSC, AIH, Crohn's disease or ulcerative disease in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of PSC, AIH, Crohn's disease and ulcerative colitis in tissue samples.
A method for identifying an individual having a disorder comprising a step of detecting a presence or absence of a Primary Sclerosing Cholangitis, hereinafter, PSC, associated retroviral nucleic acid molecule, wherein said nucleic acid molecule comprises SEQ ID NOs:
A composition comprising an isolated Primary Sclerosing Cholangitis, PSC, associated retrovirus encoded by a genome comprising a nucleotide sequence comprising SEQ. ID. NOs. 1, 2, 3,4, 5, 6, 7, or the compliment thereof.
A method for identifying an individual infected with the Primary Sclerosing Cholangitis, hereafter PSC, associated retrovirus comprising detection of a PSC associate retroviral nucleic acid molecule wherein said nucleic acid molecule comprises SEQ. ID. NOs. 1, 2, 3, 4, 5, 6, 7, or the compliment thereof, wherein the presence of the nucleic acid molecule indicates that the individual is infected with the PSC associated retrovirus.
A method for identifying an in vitro sample infected with the Primary Sclerosing Cholangitis, hereafter PSC, associated retrovirus comprising the step of detecting the presence or absence of the PSC associated Retroviral nucleic acid molecule wherein said nucleic acid molecule comprises SEQ. ID. NOs. 1, 2, 3, 4, 5, 6, 7, or the compliment thereof, wherein the presence of the nucleic acid molecule indicates that the sample is infected with the PSC associated retrovirus.
Dependencies are inferred from the claim text.