Sterilization of bioactive coatings

A method of sterilizing a material comprising:

• applying a bioactive coating comprising polymerizable chemical to said material;
• polymerizing said bioactive coating on said material;
• and simultaneously or thereafter
• sterilizing said material and said bioactive coating with a sterilization process comprising generating a hydrogen peroxide gas plasma with a frequency of 0.1 MHz to 30 MHz, without significantly impacting the bio-activity of the coating.

A method of sterilizing a material comprising:

• applying a bioactive coating comprising polymerizable chemical to said material;
• polymerizing said bioactive coating on said material;
• and simultaneously or thereafter
• sterilizing said material and said bioactive coating with a sterilization process comprising generating a hydrogen peroxide gas plasma, without significantly impacting the bio-activity of the coating, wherein the material is selected from the group consisting of stainless steel, aluminum, nitinol, cobalt chrome, and titanium.

A method of sterilizing a material comprising:

• applying a bioactive coating comprising polymerizable chemical to said material;
• polymerizing said bioactive coating on said material;
• and simultaneously or thereafter
• sterilizing said material and said bioactive coating with a sterilization process comprising generating a hydrogen peroxide gas plasma, without significantly impacting the bio-activity of the coating, wherein the material is selected from the group consisting of polylactic acid, polyglycolic acid, polycaprolactone, polyparadioxanone, polytrimethylene carbonate and their copolymers, collagen, elastin, chitin, coral, hyaluronic acid, bone and combinations thereof.

A method of sterilizing a material comprising:

• applying a bioactive coating comprising polymerizable chemical to said material;
• polymerizing said bioactive coating on said material;
• and simultaneously or thereafter
• sterilizing said material and said bioactive coating with a sterilization process comprising generating a hydrogen peroxide gas plasma, without significantly impacting the bio-activity of the coating, wherein the bioactive coating comprises heparin, phophoryl choline, urokinase or rapamycin.

A method of sterilizing a material comprising:

• applying a bioactive coating comprising polymerizable chemical to said material;
• introducing a biological indicator;
• polymerizing the bioactive coating on the material;
• and
• sterilizing the material with the bioactive coating and the biological indicator with a sterilization process comprising generating a hydrogen peroxide gas plasma.