Process for treatment of a lactic raw material

A process for obtaining a fraction of lactic raw material enriched in glycomacropeptide or caseinoglycomacropeptide (“GMP”) comprising the steps of:

• deionizing a lactic raw material for a time sufficient to obtain a substantially deionized lactic raw material having a pH of about 1 to 4.5 with the pH being adjusted, if necessary, to the recited range;
• contacting the substantially deionized lactic raw material with an anionic resin having a hydrophobic matrix for a sufficient amount of time and at a sufficient temperature to remove GMP from the substantially deionized lactic raw material and to obtain a treated liquid material, wherein the substantially deionized lactic raw material contacts the resin in a gently stirred reactor at a temperature of less than 50° C. for one to ten hours to adsorb the:
• GMP onto the resin;
• separating the resin from the treated liquid material;
• and
• separating the GMP enriched fraction from the resin.

A process for the extraction and removal of glycomacropeptide or caseinoglycomacropeptide (“GMP”) from a lactic raw material comprising the steps of:

• deionizing a lactic raw material for a time sufficient to obtain a substantially deionized lactic raw material having a pH of about 1 to 4.5 with the pH being adjusted, if necessary, to the recited range;
• contacting the substantially deionized lactic raw material with an anionic resin having a hydrophobic matrix for a sufficient amount of time and at a sufficient temperature to remove GMP from the substantially deionized lactic raw material by adsorbing a substantial amount of GMP onto the anionic resin to obtain a treated liquid material that does not contain substantial amounts of GMP;
• separating the resin from the treated liquid material;
• concentrating the treated liquid material by evaporation and drying;
• and
• recovering GMP by desorbing it from the resin.

A process for obtaining a fraction of a lactic raw material enriched in glycomacropeptide or caseinoglycomacropeptide (“GMP”) comprising the steps of:

• deionizing a lactic raw material for a time sufficient to obtain a substantially deionized lactic raw material having a pH of about 1 to 4.5 with the pH being adjusted, if necessary, to the recited range;
• treating the resin with an alkaline material;
• contacting the substantially deionized lactic raw material with an anionic resin having a hydrophobic matrix for a sufficient amount of time and at a sufficient temperature to adsorb a substantial amount of GMP onto the anionic resin from the substantially deionized lactic raw material and to obtain a treated liquid material that does not contain substantial amounts of GMP;
• separating the resin from the treated liquid material;
• and
• separating the adsorbed GMP enriched fraction from the resin.

A process for preparing a composition that contains glycomacropeptide or caseinoglycomacropeptide (“GMP”) in combination with a pharmaceutically acceptable carrier, said process comprising the steps of:

• (a) deionizing a lactic raw material for a time sufficient to obtain a substantially deionized lactic raw material having a pH of about 1 to 4.5 with the pH being adjusted, if necessary, to the recited range;
• (b) contacting the substantially deionized lactic raw material with an anionic resin having a hydrophobic matrix for a sufficient amount of time and at a sufficient temperature to adsorb a substantial amount of GMP onto the anionic resin from the substantially deionized lactic raw material and to obtain a treated liquid material that does not contain substantial amounts of GMP;
• (c) separating the resin from the treated liquid material;
• (d) separating the adsorbed GMP enriched fraction from the resin;
• and
• (e) combining the GMP of step (d) with a pharmaceutically acceptable carrier.

A process for obtaining a composition comprising a carrier and a fraction of a lactic raw material enriched in glycomacropeptide or caseinoglycomacropeptide (“GMP”), wherein said process comprises the steps of:

• deionizing a lactic raw material for a time sufficient to obtain a substantially deionized lactic raw material having a pH of about 1 to 4.5 with the pH being adjusted, if necessary, to the recited range;
• contacting the substantially deionized lactic raw material with an anionic resin having a hydrophobic matrix for a sufficient amount of time and at a sufficient temperature to adsorb a substantial amount of GMP onto the anionic resin from the substantially deionized lactic raw material and to obtain a treated liquid material that does not contain substantial amounts of GMP;
• separating the resin from the treated liquid material;
• separating the adsorbed GMP enriched fraction from the resin;
• and
• combining said GMP enriched fraction with a carrier;
• wherein said process the GMP enriched fraction includes less than 1% by weight of fat, less than 0.2% by weight of lactose, and less than 3% by weight of true whey products.