Prevention and treatment of amyloidogenic disease
AssigneeNeuralab Limited
InventorDale B. Schenk
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
Claims24
A composition comprising an Aβ fragment linked to a cholera toxoid carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances immune response comprising antibodies to the Aβ fragment.
A method of preventing or treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ fragment and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ fragment and thereby prevent or treat the disease in the patient wherein the Aβ fragment is linked to a cholera toxoid carrier molecule to form a conjugate, and the adjuvant enhances the immune response to the Aβ fragment.
Dependencies are inferred from the claim text.