Prevention and treatment of amyloidogenic disease
AssigneeNeuralab Limited
InventorDale B. Schenk
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
Claims43
A method of prophylactically or therapeutically treating a disease characterized by an amyloid deposit of Aβ in a patient, comprising:
- administering an Aβ peptide and a 3 De-O-acylated monophosphoryl lipid A (MPL) adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ peptide and thereby prophylactically or therapeutically treat the disease in the patient.
A pharmaceutical composition effective to induce an immunogenic response against Aβ in a patient comprising an Aβ peptide and a 3 De-O-acylated monophosphoryl lipid A (MPL) adjuvant.
Dependencies are inferred from the claim text.