Prevention and treatment of amyloidogenic disease
AssigneeNeuralab Limited
InventorDale B. Schenk
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
Claims36
A composition comprising an Aβ fragment linked to a canier molecule to form a conjugate and an adjuvant wherein the adjuvant enhances an immune response comprising antibodies to the Aβ fragment.
A method of prophylactically or therapeutically treating a disease characterized by an amyloid deposit of Aβ in a patient comprising:
- administering an Aβ fragment and an adjuvant in a regime effective to induce an immune response comprising antibodies to the Aβ fragment and thereby prophylactically or therapeutically treat the disease in the patient, wherein the Aβ fragment is linked to a carrier molecule to form a conjugate, and the adjuvant enhances the immune response to the Aβ fragment.
Dependencies are inferred from the claim text.