Methods and compositions for treatment of inflammatory disease using cadherin-11 modulating agents
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsMichael B. Brenner, Xavier Valencia
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Abstract
A method for treating inflammatory joint diseases by inhibiting cadherin-11 mediated cellular function using a cadherin-11 modulating agent is provided. Also provided are screening assays for identifying pharmaceutical lead compounds capable of modulating cellular functions of cadherin-11 such as cell proliferation, apoptosis, factor secretion, and binding of cadherin-11 to cadherin-11 counter-receptor inhibiting binding of cadherin-11 to its counter-receptor either in the context of a cell or in soluble form.
Claims11
A method for treating a subject having an inflammatory joint disorder comprising
- administering to a subject in need of such treatment a therapeutically effective amount of a cadherin-11 inhibitory agent
- wherein the cadherin-11 inhibitory agent is an antibody to cadherin-11 that inhibits binding of cadherin-11 to a cadherin-11 counter-receptor that is a cadherin-11.
Dependencies are inferred from the claim text.