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US 6,787,088 B2Granted
Controlled fluid transport in microfabricated polymeric substrates
AssigneeCaliper Life Science, Inc.
InventorsJohn Wallace Parce, Michael R. Knapp, Calvin Y. H. Chow, Luc J. Bousse
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Abstract
Microfluidic devices are provided for the performance of chemical and biochemical analyzes, syntheses and detection. The devices of the invention combine precise fluidic control systems with microfabricated polymeric substrates to provide accurate, low cost miniaturized analytical devices that have broad applications in the fields of chemistry, biochemistry, biotechnology, molecular biology and numerous other fields.
Claims19
A method of making a microfluidic device, comprising:
- (a) providing a polymeric substrate having at least a first microscale chamber disposed therein, which first microscale chamber comprises at least a first surface;
- and,
- (b) providing a layer of a first modifying material on the first surface of the first microscale chamber, wherein the first modifying material is at least partially embedded in the first surface.
Dependencies are inferred from the claim text.