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US 6,784,299 B2Granted
Substituted aromatic ethers as inhibitors of glycine transport
AssigneePfizer Inc.
InventorJohn A. Lowe, III
Life of this patent
Estimating the term…
Abstract
This invention relates to a series of substituted aromatic ethers of the formula I wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
Claims13
A compound of the formula I
- wherein ring A is benzothienyl, benzofuranyl, or pyridyl;
- and
- X and Y are each, independently, (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms;
- (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms, wherein the number of fluorine substituents on the foregoing (C1-C6)alkyl and (C1-C6)alkoxy groups can not exceed the number of positions in such groups that are available for substitution;
- carboxy;
- carbo-(C1-C6)alkoxy;
- carboxamido;
- (C1-C6)alkyl-thio;
- sulfoxyl;
- sulfonyl;
- halo;
- nitro;
- cyano;
- amino;
- (C1-C6) alkylamino and di{(C1-C6)alkyl}amino;
- B is (C1-C6)alkyl, (C1-C6)alkoxy optionally substituted with 1 to 7 fluorine atoms, or halogen;
- or a pharmaceutically acceptable salt thereof.
14 more elements
A compound having the formula:
- wherein Y is (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms;
- (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms, wherein the number of fluorine substituents on the foregoing (C1-C6)alkyl and (C1-C6) alkoxy groups can not exceed the number of positions in such groups that are available for substitution;
- carboxy;
- carbo-(C1-C6)alkoxy;
- carboxamido;
- (C1-C6)alkyl-thio;
- sulfoxyl;
- sulfonyl;
- halo;
- nitro;
- cyano;
- amino;
- (C1-C6) alkylamino and di{(C1-C6)alkyl}amino;
- wherein Z1 and Z2 are independently selected from O, NH, N—(C1-C5 alkyl), and S;
- and n is an integer from 1 to about 3;
- or a pharmaceutically acceptable salt thereof.
13 more elements
A compound having the formula:
- wherein Y is (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms;
- (C1-C6)alkoxy optionally substituted with from one to seven fluorine atoms, wherein the number of fluorine substituents on the foregoing (C1-C6)alkyl and (C1-C6) alkoxy groups can not exceed the number of positions in such groups that are available for substitution;
- carboxy;
- carbo-(C1-C6)alkoxy;
- carboxamido;
- (C1-C6)alkyl-thio;
- sulfoxyl;
- sulfonyl;
- halo;
- nitro;
- cyano;
- amino;
- (C1-C6) alkylamino and di{(C1-C6)alkyl}amino;
- wherein Z1 and Z2 are independently selected from O, NH, N—(C1-C5 alkyl), and S;
- and n is an integer from 1 to about 3;
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.