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AssigneeHer Majesty the Queen in right of Canada, as represented by the Minister of Agriculture and Agri-Food
InventorsThérèse Ouellet, Brian M. Miki, Elizabeth Foster, Teresa Martin-Heller, Lining Tian, Daniel C. Brown, Peijun Zhang, Jiro Hattori, Kamal Malik, Keqiang Wu, David A. Theilmann, Raymond Tropiano
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The present invention is directed to translational regulatory elements that mediate the amount of protein produced within a host capable of expressing a construct comprising one or more translational regulatory elements in operative association with a gene of interest. These translational regulatory elements were derived from T1275 (tCUP) and exhibit a high degree of similarity with members of the RENT family of repetitive elements. Translational regulatory elements are disclosed that either increase or decrease he amount of protein produced within the host organism. These translational elements are operative in a wide range of hosts including plant, animals, yeast, fungi and bacteria. Analogs, derivatives and fragments of these translational elements are also disclosed.
An isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid consisting of nucleotides 1-16 of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid consisting of nucleotides 10-24 of the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid consisting of two copies of the nucleotide sequence of SEQ ID NO:
Dependencies are inferred from the claim text.