Modifying tissue surfaces by liquid crystal formation
OwnerJulia Hwang, Samuel I. Stuppinventors
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Abstract
A method for modifying the surface properties of tissue in vivo is described. The method comprises forming a liquid crystalline matrix on the tissue surface wherein the matrix comprises a tissue surface component. In one embodiment there is provided a method for improving the bonding of surgical glues and cements to cartilage and other synovial fluid wetted tissue surfaces. Such surfaces are contacted with a composition comprising a poly(hydroxy substituted amino acid) to form a liquid crystalline matrix on the tissue surface. The matrix is readily removed to provide a tissue surface that exhibits improved bonding with surgical glues.
Claims22
A method for preparing a cartilage surface wetted with a body fluid to promote bonding of the surface with a surgical glue, the method comprising:
- contacting the cartilage surface with a polypeptide in an amount effective to form a gelatinous mesomorphic matrix on the cartilage surface prior to application of the surgical glue, wherein the polypeptide comprises a poly(hydroxy substituted amino acid) selected from the group consisting of homopolymers, copolymers, terpolymers, and block copolymers of threonine, serine, tyrosine, hydroxyproline, and 5-hydroxylysine, and wherein the body fluid comprises a synovial fluid.
A method for preparing a cartilage surface wetted with a body fluid to promote bonding of the surface with a surgical glue, the method comprising:
- contacting the cartilage surface with a polypeptide in an amount effective to form a gelled liquid crystalline matrix on the cartilage surface prior to application of the surgical glue, wherein the polypeptide comprises a poly(hydroxy substituted amino acid) having a molecular weight in the range from about 3,000 daltons to about 100,000 daltons and selected from the groups consisting of homopolymers, copolymers, terpolymers, and block copolymers of threonine, serine, tyrosine, hydroxyproline, and 5-hydroxylysine, and wherein the body fluid comprises a synovial fluid.
A method for preparing a joint tissue surface wetted with a body fluid to promote bonding of the surface with a surgical glue, the method comprising the steps of:
- contacting the tissue surface with a polypeptide in an amount effective to form a liquid crystalline matrix on the tissue surface, wherein the polypeptide comprises a poly(hydroxy substituted amino acid) selected from the groups consisting of homopolymers, copolymers, terpolymers, and block copolymers of threonine, serine, tyrosine, hydroxyproline, and 5-hydroxylysine;
- and
- applying a surgical glue to the contacted surface,
- wherein the body fluid comprises a synovial fluid.
Dependencies are inferred from the claim text.