Process for removing bile salts from a patient and alkylated compositions therefor
AssigneeGenzyme Corporation
InventorsW. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Abstract
The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of a salt of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer salt comprises the reaction product of crosslinked polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent.
Claims13
A composition comprising an alkylated and crosslinked polymer and salts thereof comprising the reaction product of:
- (a) one or more polymers, or salts and copolymers thereof having a repeat unit with the formula:
- where n is a positive integer and each R, independently, is H or a C1-C8 alkyl group;
- (b) at least one aliphatic alkylating agent;
- and
- (c) a crosslinking agent, wherein said reaction product has:
- (i) at least some of the nitrogen atoms in said repeat units unreacted with said alkylating agent;
- and
- (ii) less than 10 mol % of the nitrogen atoms in said repeat units that react with said alkylating agent form quaternary ammonium units.
Dependencies are inferred from the claim text.