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US 6,784,202 B1Granted
Cubane derivatives as metabotropic glutamate receptor agonists or antagonists and process for their preparation
AssigneePrescient NeuroPharma Inc.
InventorsHassan Pajouhesh, Kenneth Curry
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Abstract
The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.
Claims10
A compound of the formula:
- wherein:
- R1 is carboxyl;
- R2 is a basic group selected from the group consisting of 1° amino, 2° amino, and 3° amino;
- R3 is CH2-thioxanthyl;
- R4 is carboxyl;
- and pharmaceutically acceptable salts thereof.
3 more elements
A method of treating cerebral ischemia, stroke and cardiac arrest in a warm blooded mammal comprising administering an effective amount of the compound:
- to a warm blooded mammal in need thereof.
Dependencies are inferred from the claim text.